Management and outcome in a Swedish population

....................................................................................................................... 7 List of abbreviations .................................................................................................. 9 List of publications..................................................................................................... 11 Thesis at a glance........................................................................................................ 13 Introduction................................................................................................................. 15 Background................................................................................................................. 17 Epidemiology....................................................................................................... 17 Aetiology.............................................................................................................. 18 Diagnosis and preoperative staging..................................................................... 19 Management......................................................................................................... 20 Recurrence............................................................................................................ 27 Survival................................................................................................................. 28 Quality registers.................................................................................................... 29 Aims..............................................................................................................................31 Papers of the thesis..................................................................................................... 33 Methods................................................................................................................ 33 Statistical methods................................................................................................ 33 Colon cancer management and outcome in relation to individual hospitals in a defined population (Paper I)...................................... 35 Patients...................................................................................................... 35 Results....................................................................................................... 35 Loco-regional recurrence from colon cancer: a population-based study (Paper II)................................................................. 38 Patients...................................................................................................... 38 Results....................................................................................................... 38 The potential for improved outcome in patients with hepatic metastases from colon cancer: a population-based study (Paper III).............. 42 Patients...................................................................................................... 42 Results....................................................................................................... 43 Tumour volume as a prognostic factor in colon cancer (Paper IV).................45 Patients...................................................................................................... 45 Results....................................................................................................... 45